Blar i forfatter "Schneider, Yannik Karl-Heinz"
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Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.
Schneider, Yannik Karl-Heinz; Østnes Hansen, Kine; Isaksson, Johan; Ullsten-Wahlund, Sara Maria; Hansen, Espen; Andersen, Jeanette Hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)Two bacterial isolates from the Barents Sea, both belonging to the genus <i>Algibacter</i>, were found to yield extracts with anti-bacterial bioactivity. Mass spectrometry guided dereplication and purification of the active extracts lead to the isolation of the same active principle in both extracts. The structure of the bioactive compound was identified via mass spectrometry and nuclear resonance ... -
Bacterial Natural Product Drug Discovery for New Antibiotics: Strategies for Tackling the Problem of Antibiotic Resistance by Efficient Bioprospecting
Schneider, Yannik Karl-Heinz (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-10)The problem of antibiotic resistance has become a challenge for our public health and society; it has allowed infectious diseases to re-emerge as a risk to human health. New antibiotics that are introduced to the market face the rise of resistant pathogens after a certain period of use. The relatively fast development of resistance against some antibiotics seems to be closely linked to their microbial ... -
Bioactive secondary metabolites from bacteria. Natural products from marine and terrestrial bacteria, dereplication, isolation and investigation of bacterial secondary metabolites
Schneider, Yannik Karl-Heinz (Doctoral thesis; Doktorgradsavhandling, 2020-09-29)The thesis gives an introduction to natural product drug discovery and the underlying chemical principles that make natural products privileged structures for drug discovery. Paper I deals with the isolation of Lipid 430 from cultures of two <i>Algibacter</i> sp. isolates and the investigation of their anti-proliferative and anti-bacterial effect. Paper II describes the isolation of Serratiochelin ... -
Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp.
Schneider, Yannik Karl-Heinz; Jenssen, Marte; Isaksson, Johan; Østnes Hansen, Kine; Andersen, Jeanette Hammer; Hansen, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)Siderophores are compounds with high affinity for ferric iron. Bacteria produce these compounds to acquire iron in iron-limiting conditions. Iron is one of the most abundant metals on earth, and its presence is necessary for many vital life processes. Bacteria from the genus <i>Serratia</i> contribute to the iron respiration in their environments, and previously several siderophores have been isolated ... -
Qualitative and Quantitative Comparison of Liquid–Liquid Phase Extraction Using Ethyl Acetate and Liquid–Solid Phase Extraction Using Poly-Benzyl-Resin for Natural Products
Schneider, Yannik Karl-Heinz; Andersen, Jeanette Hammer; Hansen, Espen; Jørgensen, Solveig M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-01)A key step in the process of isolating microbial natural products is the preparation of an extract from a culture. This step determines which molecules will be available for detection in the subsequent chemical and biological analysis of a biodiscovery pipeline. In the present study we wanted to document potential differences in performance between liquid–liquid extraction using ethyl acetate ...